Epidemics, emergencies and disasters raise many ethical issues for the people involved, including first responders, public health specialists and policy‑makers. This training manual is a practical resource, designed to help organize and run training days and courses. Issues are organized into competencies, with introductions to the topics, background readings, case studies, discussion questions and PowerPoint slides. Specific instructional strategies are included, along with recommended timings for various components of the training sessions. This manual provides material on ethical issues in research, surveillance and patient care in these difficult contexts, as well as ways to reduce risks before, during and after events. The manual originated from a WHO technical consultation on Research ethics in international epidemic response (World Health Organization, 2010). The experts took positions on three main issues: “the principles and values embodied in international and national ethics guidelines, as well as human rights instruments, must be upheld” in the conduct of research in epidemic response; they expressed reluctance to ground the need for ethical oversight on the classical distinction between health practice and research recognizing that such a distinction easily becomes blurred during emergencies: the experts considered a number of adaptations of ethical oversight and processes, focusing on the deliberations of research ethics committees. The technical consultation reaffirmed the importance of addressing the conflicts among various ethical considerations during research, surveillance and patient care in emergencies, including access to standards of care, confidentiality, the duty to care, fairness, informed consent, liberty, moral relativism and privacy.